The series depicts a ghost baby girl from the positive side of the afterlife called Mundo De Los Espiritus named Conchita who is sent to Earth by a skeleton boatman and ends up at the home of the Sanchez Family in the town of Spirit Creek a.k.a The Human World.Conchita often finds herself in predicaments due to her perpetual black pacifer and her red hat.
- Conchita (voiced by Genesis Ochoa in the pilot, Melany Ochoa in the series), a cute ghost girl who is sent to Earth to live with the Sanchez family as her parents.
- Reggie Sanchez (voiced by Rico Rodriguez), the 12 year old son of the Sanchez family. When Conchita arrives on Earth, He takes care of Conchita.
- Cassidy "Cassy" Manson (voiced by Grey DeLisle),Reggie's female best friend who has the ability to see and talk to dead people.
- Jacob"Jake"Martinez (voiced by Daneboe): A lighthearted teenager obsessed with horror movies, Like Cassidy, he shares the ability to see and talk to dead people.